St. Luke's Episcopal Hospital is conveniently located on the southwest edge of downtown Houston, close to freeways and major thoroughfares. To get the lastest traffic information, visit Houston Transtar's site, which includes a real-time traffic map.

Click here to get driving directions from MapQuest.

From Bush Intercontinental Airport/Highway 59 South:
Depart Intercontinental Airport onto Will Clayton Boulevard
Take Will Clayton to Highway 59 South
Take Highway 59 South for 17 miles
Take the TX-288 South exit toward Freeport/Lake Jackson
After two miles, take the Holcombe Blvd./Old Spanish Trail exit
Turn right onto Holcombe Blvd.
After one and a half miles, turn right on Richard J.V. Johnson Ave.

From Hobby Airport/I-45 North:
Depart Hobby Airport onto Broadway
Take Broadway to I-45 North
Exit I-45 North onto the 610 Loop West
Follow 610 Loop West and exit TX-288 North toward downtown
After less then one mile on TX-288, take the Yellowstone Blvd. exit
After one half mile, turn left onto Holcombe Blvd.
After one and a half miles, turn right on Richard J.V. Johnson Ave.

From San Antonio (traveling East):
I-10 East to I-610 South to US 59 North
Take Kirby Dr. exit South (turn right)
After two miles, turn left onto Holcombe Blvd.
After one mile, turn left on Richard J.V. Johnson Ave.

From New Orleans, LA (traveling West):
I-10 West to US 59 South to TX 288 South
After two miles, take the Holcombe Blvd./Old Spanish Trail exit
Turn right onto Holcombe Blvd.
After one and a half miles, turn right on Richard J.V. Johnson Ave.

From Dallas (traveling South):
I-45 South to TX 288 South
After two miles, take the Holcombe Blvd./Old Spanish Trail exit
Turn right onto Holcombe Blvd.
After one and a half miles, turn right on Richard J.V. Johnson Ave.

From Highway 59 (traveling North):
Highway 59 North
Take Kirby Dr. exit South (turn right)
After two miles, turn left onto Holcombe Blvd.
After one mile, turn left on Richard J.V. Johnson Ave.